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耗竭T细胞,将功能性治愈率从不足10%提升至30%,其中低HBsAg(<1000 IU/mL)患者可达47%。反义寡核苷酸(ASO)如Bepirovirsen及国产AHB-137,可精准沉默病毒基因,同步压制HBsAg与HBV DNA,并干预cccDNA转录产物。核衣壳调节剂(如广生堂GST-HG141)通过干扰衣壳组装阻断病毒成熟,间接耗竭cccDNA库,其与HBsAg抑制剂(如GST-H

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